The algorithm evaluates multiple morphological features to find the best-matching atlas plate:
- Ventricle geometry: lateral ventricle shape changes substantially along the AP axis
- Hippocampal formation: the presence, size, and curvature of hippocampal layers
- Cortical features: thickness and layering patterns vary by AP level
- Subcortical nuclei: the appearance of thalamic, hypothalamic, and striatal structures